Crinetics Pharmaceuticals

CRNX Pending acquisition Rare disease Lead: Approved 8 Biotech Distilled articles ↓

Most recent annual filing: 2026-02-15

Catalyst timeline

CRN09682 Ph1 readout2026CRN09682 Ph1 readout, 2026, material
Merger closing partnership3Q 2026Merger closing partnership, 3Q 2026, routine
Merger with Vertex strategic reviewSep 2026Merger with Vertex strategic review, Sep 2026, routine
Merger agreement strategic reviewJan 6, 2027Merger agreement strategic review, Jan 6, 2027, routine

Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.

Pipeline (6 active programs)

PALSONIFY

paltusotine

Small Molecule Target: SST2, somatostatin receptor 2, somatostatin receptor

Acromegaly Approved oral Sanwa Kagaku Kenkyusho NCT03789656
Carcinoid Syndrome Phase 3 oral NCT05361668

atumelnant

CRN04894

Small Molecule Target: ACTH receptor, MC2R, melanocortin receptor, CRF1, corticotropin-releasing factor receptor 1

Congenital Adrenal Hyperplasia Phase 3 oral NCT05907291
ACTH-Dependent Cushing's Syndrome Phase 1 Phase 1b/2a trial oral National Institute of Diabetes and Digestive and Kidney Diseases NCT05804669
Adrenal Crisis Phase 2

CRN09682

Small Molecule Target: SST2, somatostatin receptor 2

Neuroendocrine Tumors Phase 1 NCT07129252

Technology platforms

NDC

Non-peptide drug conjugate (NDC) platform linking SST2 agonists with cytotoxic payloads via cleavable linkers for targeted delivery to SST2-expressing tumor cells; focus on neuroendocrine tumors and other SST2-positive solid tumors including SCLC, meningioma, head and neck cancer, and breast cancer

Targets: SST2, somatostatin receptor 2

Biotech Distilled coverage (8)

2026-08-15 UPDATE: Crinetics Pharmaceuticals (CRNX) - The Antitrust Gate Opens
2026-08-04 UPDATE: Crinetics Pharmaceuticals (CRNX) - The Last Quarter as a Public Company
2026-07-06 UPDATE: Crinetics Pharmaceuticals (CRNX) - Vertex Pays $10 Billion for the Pipeline-in-a-Pill
2026-06-15 UPDATE: Crinetics Pharmaceuticals (CRNX) — The ENDO Data Dump
2026-05-09 UPDATE: Crinetics Pharmaceuticals (CRNX) — Sell-the-News Decoded 🔒 Paid
2026-05-08 UPDATE: Crinetics Pharmaceuticals (CRNX) — The Q1 Print Lands in the Bull Range 🔒 Paid
2026-04-28 UPDATE: Crinetics Pharmaceuticals (CRNX) — The EC Catalyst Hits 🔒 Paid
2026-04-02 Crinetics Pharmaceuticals (CRNX) - Scientific Deep Dive for Paltusotine and Pipeline Products 🔒 Paid

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