Biocryst Pharmaceuticals
Market cap $1.98B 257.3M shares (10-Q, Oct 30, 2026) × $7.69 close Nov 6, 2026
Most recent annual filing: 2026-02-26
- BCX17725 Ph1 readoutby year-end 2026BCX17725 Ph1 readout, by year-end 2026, notable
- deucrictibant Pharvaris NDA filing1H 2027deucrictibant Pharvaris NDA filing, 1H 2027, material
- lonvo-z Intellia PDUFA dateMar 10, 2027lonvo-z Intellia PDUFA date, Mar 10, 2027, major
- deucrictibant Pharvaris PDUFA dateApr 23, 2027deucrictibant Pharvaris PDUFA date, Apr 23, 2027, major
- navenibart topline3Q 2027navenibart topline, 3Q 2027, thesis-defining
- ORLADEYO corporate update~Jul 2027ORLADEYO corporate update, ~Jul 2027, notable
- navenibart filingby year-end 2027navenibart filing, by year-end 2027, material
- ORLADEYO ANDA corporate updateDec 6, 2027ORLADEYO ANDA corporate update, Dec 6, 2027, routine
Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.
Pipeline (4 active programs)
RAPIVAB
peramivirnavenibart
STAR-0215BCX17725
Discontinued (2)
- avoralstat — Diabetic Macular Edema · In the first quarter of 2026, BioCryst ended development of avoralstat for diabetic macular edema to focus the pipeline on rare diseases (10-Q 2026-05-06; NCT07228559 TERMINATED)
- STAR-0310 — Atopic Dermatitis · BioCryst: 'We plan to seek strategic alternatives for this asset' (10-K 2026-02-26; 10-Q 2026-05-06); program R&D $683K Q1 2026 -> $91K Q2 2026
Capital (as filed)
- Cash
- $97.0M cash and cash equivalents · Sep 30, 2026 (10-Q)
- Short-term investments
- $278M Sep 30, 2026
- Operating cash flow
- $33.0M quarter Jun 30, 2026 → Sep 30, 2026, year-to-date difference (10-Q)
- As stated in coverage
- $375M cash per the update of Nov 4, 2026 — the company's own words as read there, not the filed figure
Cash, investments and operating cash flow are the company's own XBRL facts as filed with the SEC, each shown with its period end and tag. As-stated figures come from the company's own words as read in Biotech Distilled coverage, dated, and routinely count securities and planned financing that a balance sheet does not. Offering rows are the SEC cover pages as filed. Not investment advice. Figures as of Nov 7, 2026.
Biotech Distilled coverage (2)
- 2026-11-05 UPDATE: BioCryst Pharmaceuticals (BCRX) - The Inventory Quarter 🔒 Paid
- 2026-09-16 BioCryst Pharmaceuticals (BCRX) - Scientific Deep Dive for ORLADEYO, Navenibart, and Pipeline Products 🔒 Paid
Articles open on Substack. Some are subscriber-only; those marked ★ Distilled Pro are for Distilled Pro members.
Verdict history (2 calls)
Every verdict Biotech Distilled has published on Biocryst Pharmaceuticals, oldest first — the full history, never a selection. How calls are scored: the track record.
- 2026-09-16 Watch BioCryst Pharmaceuticals (BCRX) - Scientific Deep Dive for ORLADEYO, Navenibart, and Pipeline Products Cash flows and 2035 patent floor are real, but the terminal-value question—whether ORLADEYO's oral convenience moat survives a superior oral competitor—has a dated answer arriving in 2027, and the uncertainty is not compensated at current prices.
- 2026-11-05 Watch UPDATE: BioCryst Pharmaceuticals (BCRX) - The Inventory Quarter Q3 headline beat was driven by a one-time CareMed stocking order masking flat underlying ORLADEYO revenue, adult capsule volume is already slipping, and neither de-risking trigger for an upgrade has fired.
Every verdict Biotech Distilled has published on this company, in order, with the post it came from — the full history, never a selection. Position figures are the same ones shown on /track-record, computed by the same method. Editorial opinion, not investment advice.
Timing, in the company's words (2 quotes from 2 filings)
Sentences quoted verbatim from the company's SEC filings, newest filing first. Each sits under the filing it appeared in; the "matched to" tag names the calendar row it was read for.
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“Looking to our pipeline, BCX17725 remains on track for the early clinical data by the end of this year, and we look forward to navenibart pivotal results in the third quarter of 2027.”
matched to navenibart · topline data · read as third quarter of 2027
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“The program remains on track to report top-line results from both doses in Q3 2027.”
matched to navenibart · topline data · read as Q3 2027
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Timing sentences quoted from the company's own SEC filings, each under the filing it appeared in. The 'matched to' tag is the calendar row the sentence was read for; the filing is the source. Not investment advice.
Filings & releases (18)
SEC filings from EDGAR and press releases captured from the company's investor-relations site, newest first. Releases captured from Oct 5, 2026; filings from March 2026. Summaries come from the BD update that read the document; "BD extracted" counts point at the pipeline table above. All companies →
- Nov 4, 2026ReleaseBioCryst Reports Third Quarter 2026 Financial Results→ BD updateSummary on the 8-K
- Nov 4, 2026ReleaseBioCryst to Present at Upcoming Investor Conferences→ BD updateSummary on the 8-K
- Nov 4, 20268-KCurrent report: results of operations, Reg FD disclosure · EX-99.1 PRESS RELEASE→ BD updateBioCryst's Q3 print cleared the CareMed transition risk and accelerated the OMERS royalty-cap timeline, but investors should understand that headline ORLADEYO revenue was flattered by a mid-teens inventory build — the underlying business is tracking, not accelerating.
- Nov 4, 202610-QQuarterly report→ BD updateSummary on the 8-K
- Oct 29, 2026ReleaseBioCryst to Present New Data for ORLADEYO® (berotralstat) and Navenibart at the 2026 American College of Allergy, Asthma & Immunology Annual Scientific Meeting
- Oct 21, 2026ReleaseBioCryst Announces U.S. FDA Approval of ORLADEYO® 150 mg Oral Pellets for Adults and Adolescents with HAESummary on the release
- Oct 21, 2026ReleaseBioCryst to Report Third Quarter 2026 Financial Results on November 4The FDA just expanded ORLADEYO's pellet formulation to adults and adolescents who can't or won't swallow a capsule — a small but real label win that shores up ORLADEYO's "first and only oral HAE prophylactic for ages 2+" positioning heading into two competitor PDUFA dates in 2027.
- Oct 5, 2026ReleaseBioCryst Announces Formation of Scientific Advisory Board to Drive Rare Disease Pipeline Innovation and Growth
- Aug 5, 20268-KCurrent report: results of operations, Reg FD disclosure · EX-99.1 PRESS RELEASE
- Aug 5, 202610-QQuarterly report
- Aug 4, 20268-K/ACurrent report (amended): exit / restructuring costs
- Jun 29, 20268-KCurrent report: exit / restructuring costs, Reg FD disclosure · EX-99.1 PRESS RELEASE
- Jun 12, 20268-KCurrent report: officer / director change, shareholder vote
- May 6, 20268-KCurrent report: results of operations, Reg FD disclosure · EX-99.1 PRESS RELEASE
- May 6, 202610-QQuarterly report
- May 4, 20268-KCurrent report: Reg FD disclosure · EX-99.1 PRESS RELEASE
- Apr 23, 2026DEFA14AProxy soliciting material
- Apr 23, 2026DEF 14AProxy statement
7 more filings (13G holder notices, S-8, proxy material, SEC correspondence …)
- Aug 14, 2026SCHEDULE 13G/A13G amendment
- Aug 7, 2026SCHEDULE 13GPassive >5% holder (13G)
- Aug 5, 2026S-8Employee plan registration
- May 12, 2026SCHEDULE 13GPassive >5% holder (13G)
- Apr 29, 2026SCHEDULE 13GPassive >5% holder (13G)
- Apr 23, 2026ARSAnnual report to shareholders
- Mar 26, 2026SCHEDULE 13G/A13G amendment