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Prelude Therapeutics

PRLD Rare disease Lead: Phase 1 1 Biotech Distilled article ↓
HematologyOncology Small Molecule

Most recent annual filing: 2026-03-10

Catalyst timeline

11 trackedQuarter catalyst calendar →
  1. mCALR DAC corporate updateBy year-end 2026mCALR DAC corporate update, By year-end 2026, routine
  2. PRT13722 trial start4Q 2026PRT13722 trial start, 4Q 2026, notable
  3. PRLD corporate updateNov 2026PRLD corporate update, Nov 2026, routine
  4. Incyte JAK2V617F next-gen readoutDec 2026Incyte JAK2V617F next-gen readout, Dec 2026, material
  5. PRT12396 Ph1 interim2027PRT12396 Ph1 interim, 2027, notable
  6. JAK2V617F program Incyte option partnershipFeb 3 – May 3, 2027JAK2V617F program Incyte option partnership, Feb 3 – May 3, 2027, material
  7. PRLD shelf registration financingMay 2027PRLD shelf registration financing, May 2027, routine
  8. Pfizer prifetrastat topline2H 2027Pfizer prifetrastat topline, 2H 2027, major
  9. Menarini MEN2312 Ph1 readoutOct 2027Menarini MEN2312 Ph1 readout, Oct 2027, notable
  10. PRLD corporate financing2Q 2028PRLD corporate financing, 2Q 2028, routine
  11. PRT12396 Ph1 readoutApr 30, 2028PRT12396 Ph1 readout, Apr 30, 2028, notable

Bar width shows how precise the guidance is — a pin is a stated date, a wide band a six-month window. Deeper blue means more of the thesis rides on the event; it is not a view on the stock.

Pipeline (3 active programs)

Technology platforms

DAC · AbCellera Biologics

Degrader Antibody Conjugate platform combining targeted protein degrader payloads (including SMARCA2/4 dual degraders) with antibodies targeting tumor-specific antigens; focus areas include myeloproliferative neoplasms (mutant CALR-expressing cells) and solid tumors with SMARCA4 mutations. In collaboration with AbCellera for up to five programs (joint discovery, development, commercialization); AbCellera also independently developing select DACs under a non-exclusive degrader payload license.

Targets: SMARCA2, SMARCA4, CALR

Degrader Antibody Conjugates · AbCellera

Proprietary degrader payload-linker platform for degrader antibody conjugates (DACs); payloads include SMARCA2/4 dual degraders (VHL- and CRBN-based) and CDK9 degraders; engineered for improved efficacy, tolerability, and developability vs. traditional cytotoxic ADC payloads; applicable across oncology indications including myeloproliferative neoplasms; payloads available for licensing to partners developing next-generation DACs.

Targets: SMARCA2, SMARCA4, CDK9, mCALR

Precision ADC Degrader Payload · AbCellera

Degrader payload platform for antibody-drug conjugates (ADCs), engineering targeted protein degraders (TPDs) as prodrug payloads with high potency and cell-line selectivity, designed for improved efficacy and tolerability over traditional cytotoxic payloads; focus areas include oncology across solid tumors and hematologic cancers

Targets: SMARCA2, SMARCA4

DAC degrader payloads · AbCellera Biologics

Next-generation degrader antibody conjugate (DAC) platform leveraging targeted protein degradation expertise; highly potent SMARCA2/4 and CDK9 degrader payloads optimized for efficacy, tolerability and developability; also developing mutant CALR (mCALR)-targeted DACs for myeloid malignancies including myelofibrosis and essential thrombocythemia

Targets: SMARCA2, SMARCA4, CDK9, mCALR

DAC · AbCellera

Degrader Antibody Conjugate platform combining proprietary SMARCA2/4 dual degrader payloads with tumor antigen-targeting antibodies; focus areas include CALR-mutant myeloproliferative neoplasms and SMARCA4-mutant cancers. Co-developed with AbCellera Biologics for up to five programs.

Targets: SMARCA2, SMARCA4, CALR

Discontinued (3)

Biotech Distilled coverage (1)

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