:root{--chrome: #0c1422;--chrome-ink: #ffffff;--chrome-ink-soft: #aeb6c2;--chrome-line: #243049;--accent: #2563eb;--accent-hover: #1d4ed8;--accent-soft: #e6f1fb;--bg: #f5f7fa;--surface: #ffffff;--ink: #18212f;--ink-soft: #5c6675;--ink-faint: #929aa6;--line: #e7eaf0;--line-strong: #d7dce4;--rare: #633806;--rare-soft: #faeeda;--ta-ink: #444441;--ta-soft: #f1efe8;--neon: var(--accent);--neon-bright: var(--accent);--neon-deep: var(--accent);--max: 1100px;--sans: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;--mono: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace}*{box-sizing:border-box}html{-webkit-text-size-adjust:100%}body{margin:0;background:var(--bg);color:var(--ink);font-family:var(--sans);font-size:16px;line-height:1.55;-webkit-font-smoothing:antialiased}.container{width:100%;max-width:var(--max);margin:0 auto;padding:0 24px}a{color:var(--accent);text-decoration:none}a:hover{text-decoration:underline}h1,h2,h3{font-weight:600;line-height:1.2;color:var(--ink);letter-spacing:-.01em}h1{font-size:2rem;margin:0 0 .3rem}h2{font-size:1.25rem;margin:2.2rem 0 1rem;padding-bottom:.45rem;border-bottom:1px solid var(--line)}h3{font-size:1.05rem;margin:0 0 .3rem}.site-header{background:var(--chrome);border-bottom:1px solid var(--chrome-line);color:var(--chrome-ink)}.header-top{display:flex;align-items:center;justify-content:space-between;gap:16px;padding:14px 24px;flex-wrap:wrap}.brand{display:flex;align-items:center;gap:12px}.brand:hover{text-decoration:none}.brand-logo{border-radius:8px;box-shadow:0 0 0 1px var(--chrome-line);display:block}.brand-text{display:flex;flex-direction:column;line-height:1.15}.brand-name{font-weight:600;font-size:1.15rem;color:#fff;letter-spacing:.005em}.header-actions{display:flex;gap:10px;align-items:center}.menu{display:none;position:relative}.menu-toggle{list-style:none;cursor:pointer;color:var(--chrome-ink);display:flex;padding:6px;border-radius:7px}.menu-toggle::-webkit-details-marker{display:none}.menu-toggle:hover{color:#fff}.menu[open] .menu-toggle{background:#ffffff14}.menu-panel{position:absolute;right:0;top:calc(100% + 8px);z-index:20;min-width:180px;background:var(--surface);border:1px solid var(--line-strong);border-radius:10px;padding:6px;display:flex;flex-direction:column;box-shadow:0 8px 28px #0c142224}.menu-panel a{color:var(--ink);font-size:.95rem;padding:9px 12px;border-radius:7px}.menu-panel a:hover{background:var(--bg);text-decoration:none}.header-nav{display:flex;gap:24px;padding:0 24px 12px;flex-wrap:wrap}.header-nav a{color:var(--chrome-ink-soft);font-size:.9rem;font-weight:500;letter-spacing:0;padding:4px 0;border-bottom:2px solid transparent}.header-nav a:hover{color:#fff;text-decoration:none;border-bottom-color:var(--accent)}.header-search{position:relative;flex:1 1 auto;max-width:420px;margin:0 8px;min-width:0}.hs-icon{position:absolute;left:12px;top:50%;transform:translateY(-50%);color:var(--ink-faint);pointer-events:none}#hdr-search{width:100%;padding:9px 12px 9px 35px;font-size:.9rem;font-family:var(--sans);color:var(--ink);background:#fff;border:1px solid var(--chrome-line);border-radius:9px}#hdr-search::placeholder{color:var(--ink-faint)}#hdr-search:focus{outline:none;border-color:var(--accent);box-shadow:0 0 0 3px #2563eb4d}.ac-list{position:absolute;left:0;right:0;top:calc(100% + 8px);z-index:40;margin:0;padding:6px;list-style:none;text-align:left;background:var(--surface);border:1px solid var(--line-strong);border-radius:12px;box-shadow:0 12px 32px #0c14222e;max-height:70vh;overflow-y:auto}.ac-item{display:flex;align-items:baseline;gap:10px;padding:9px 12px;border-radius:8px;cursor:pointer}.ac-item[aria-selected=true],.ac-item:hover{background:var(--bg)}.ac-label{font-weight:500;color:var(--ink)}.ac-sub{font-size:.82rem;color:var(--ink-faint)}.ac-type{margin-left:auto;font-size:.68rem;color:var(--ink-soft);background:var(--bg);border:1px solid var(--line);border-radius:999px;padding:2px 8px;white-space:nowrap}.ac-empty{padding:12px;color:var(--ink-faint);font-size:.9rem}.btn{display:inline-block;font-size:.85rem;font-weight:500;font-family:var(--sans);padding:7px 14px;border-radius:7px;cursor:pointer;border:1px solid transparent;white-space:nowrap}.btn-ghost{color:var(--chrome-ink);border-color:var(--chrome-line);background:transparent}.btn-ghost:hover{border-color:var(--chrome-ink-soft);color:#fff;text-decoration:none}.btn-subscribe{color:#fff;border-color:var(--accent);background:transparent}.btn-subscribe:hover{background:var(--accent);color:#fff;text-decoration:none}.btn-accent{color:#fff;background:var(--accent)}.btn-accent:hover{text-decoration:none;background:var(--accent-hover)}main{padding:0 0 64px;min-height:60vh}.site-footer{background:var(--chrome);border-top:1px solid var(--chrome-line);color:var(--chrome-ink-soft);margin-top:48px;padding:26px 0}.footer-inner{display:flex;flex-direction:column;gap:14px}.footer-actions{display:flex;gap:20px;flex-wrap:wrap}.footer-link{color:var(--chrome-ink);font-size:.85rem;font-weight:600;background:none;border:none;padding:0;cursor:pointer;font-family:var(--sans)}.footer-link:hover{color:#fff;text-decoration:underline}.footer-note{margin:0;font-size:.78rem;max-width:70ch;line-height:1.5}.chip{display:inline-block;font-size:.72rem;line-height:1;padding:4px 9px;border:1px solid var(--line-strong);border-radius:999px;color:var(--ink-soft);background:var(--surface);white-space:nowrap;text-decoration:none}a.chip:hover{border-color:var(--accent);color:var(--accent);text-decoration:none}.chip--accent{background:var(--accent-soft);border-color:transparent;color:var(--accent-hover)}a.chip--accent:hover{background:#d6e9fc;color:var(--accent-hover)}.chip--rare{background:var(--rare-soft);border-color:transparent;color:var(--rare)}.chip--ta{background:var(--ta-soft);border-color:transparent;color:var(--ta-ink)}a.chip--ta:hover{background:#e8e5dc;color:var(--ta-ink)}.chip--more{background:transparent;border-color:var(--line-strong);color:var(--ink-faint);cursor:default}.badge-phase{display:inline-block;font-size:.72rem;font-weight:600;padding:3px 8px;border-radius:5px;white-space:nowrap;background:#eef1f5;color:#586575;text-decoration:none}a.badge-phase:hover{text-decoration:none;filter:brightness(.97)}.badge-phase[data-phase=Approved],.badge-phase[data-phase="NDA Submitted"]{background:#eaf3de;color:#27500a}.badge-phase[data-phase="Phase 3"]{background:#c2dbf5;color:#0c447c}.badge-phase[data-phase="Phase 2"]{background:#d6e8fa;color:#14579e}.badge-phase[data-phase="Phase 1"]{background:#eaf2fc;color:#1d6fd0}.badge-phase[data-phase=Preclinical]{background:#eef1f5;color:#586575}.muted{color:var(--ink-faint)}.nowrap{white-space:nowrap}.tile-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(220px,1fr));gap:14px}.tile{display:block;background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:18px 20px;color:var(--ink);transition:border-color .12s}.tile:hover{text-decoration:none;border-color:var(--accent)}.tile-title{font-weight:600;font-size:1.05rem}.tile-count{font-size:1.7rem;font-weight:600;color:var(--accent);font-variant-numeric:tabular-nums}.tile-sub{font-size:.8rem;color:var(--ink-faint)}.crumb{margin:22px 0 6px;font-size:.85rem;color:var(--ink-faint)}.crumb a{color:var(--ink-soft)}.page-head{margin:4px 0 8px}.page-head .count-note{font-weight:400;font-size:.85rem;color:var(--ink-faint)}@media(max-width:640px){.container{padding:0 16px}.header-top{gap:10px}.header-actions{display:none}.menu{display:block}.header-search{order:5;flex-basis:100%;max-width:none;margin:4px 0 0}.header-nav{gap:18px;padding:0 16px 12px}h1{font-size:1.6rem}h2{font-size:1.15rem}}